According to the NCI website, the autologous anti-CD19 CAR-CD28 T cells KTE-X19 are a preparation of autologous peripheral blood T lymphocytes (PBTL) that have been transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 single chain variable fragment (scFv) coupled to the costimulatory signaling domain CD28 and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3 zeta), with potential immunostimulating and antineoplastic activities. Upon intravenous infusion and re-introduction of autologous anti-CD19 CAR-CD28 T cells KTE-X19 into the patient, these cells bind to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell-specific cell surface antigen that is expressed in all B-cell lineage malignancies. CD3 zeta is one of several membrane-bound polypeptides found in the TCR/CD3 complex; it regulates both the assembly and cell surface expression of TCR complexes. CD28 is essential for CD4+ T-cell proliferation, interleukin-2 production, and T-helper type-2 (Th2) development. KTE-X19 has the same construct as axicabtagene ciloleucel, but differs in the manufacturing process in that KTE-X19 includes specific T-cell selection and lymphocyte enrichment necessary for activity against certain B-cell malignancies.
ASCO Remembers Breast Cancer Drug Development Pioneer Dr. José Baselga
ASCO and the oncology community are deeply saddened by the passingof JoséBaselga, MD, PhD, FASCO, on March 21, 2021, at age 61. Dr. Baselga died ofCreutzfeldt-Jakob disease,a rare fatal neurodegenerative disorder, according to his family.READ MORE