Startseite Kongressberichte 2019 Annual Meeting of the American Society of Clinical Oncology 2019 Hematology Lymphoma & CLL

Choice of Oral & Poster Presentations

ORAL ABSTRACT

Tanya Siddiqi, Kathleen Anne Dorritie, Jacob Drobnyk Soumerai, Deborah Marie Stephens, et al.

TRANSCEND CLL 004: Minimal residual disease (MRD) negative responses after lisocabtagene maraleucel (Liso-Cel; JCAR017), a CD19-directed CAR T cell product, in patients (pts) with relapsed/refractory chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL).

Conclusions: In this study of heavily pretreated pts with standard- and high-risk CLL/SLL and previous ibrutinib treatment, liso-cel-related toxicities (ie, CRS and NEs), were manageable. Pts rapidly achieved CR/CRi and uMRD. Additional follow-up will be presented. Clinical trial information: NCT03331198

 

Kirsten Fischer, Othman Al-Sawaf, Jasmin Bahlo, Anna-Maria Fink, et al.

Effect of fixed-duration venetoclax plus obinutuzumab (VenG) on progression-free survival (PFS), and rates and duration of minimal residual disease negativity (MRD–) in previously untreated patients (pts) with chronic lymphocytic leukemia (CLL) and comorbidities.

Conclusions: Fixed-duration VenG induced deep (<10-6 in 1/3 of pts), high, and long lasting MRD− rates (with a low rate of conversion to MRD+ status 1 year after treatment) in previously untreated pts with CLL and comorbidities, translating into improved PFS. Clinical trial information: NCT02242942

 

POSTER @ POSTER DISCUSSION

David Jacob Andorsky, Morton Coleman, Abdulraheem Yacoub, Jason M. Melear, et al.

MAGNIFY: Phase IIIb interim analysis of induction R2 followed by maintenance in relapsed/refractory indolent non-Hodgkin lymphoma.

Conclusions: R2 therapy is active with a tolerable safety profile in patients with R/R FL and MZL, and in patients refractory to rituximab. Clinical trial information: NCT01996865

Efficacy for Induction R2 in R/R iNHL.
  ORR, % CR, % Median TTR,
mo (range)		 Median DOR,
mo (95% CI)*		 Median PFS,
mo (95% CI)*
Overall 73 45 2.7 (1.6-12.0) 36.8 (35.8-NR) 36.0 (26.5-NR)
By histology          
FL gr 1-3a 74 46 2.8 (1.6-12.0) NR (27.7-NR) 30.2 (23.0-NR)
MZL 65 38 2.7 (1.9-11.1) 35.8 (NR-NR) 38.4 (26.5-38.4)
R-refractory status          
Yes 63 40 2.8 (1.6-12.0) 35.8 (19.2-NR) 18.1 (15.5-26.5)
No 78 47 2.7 (1.6-11.6) NR (36.8-NR) NR (36.0-NR)

*If patients were already in maintenance at data cutoff, then response assessments also contributed to DOR and PFS.

 

John G. Gribben, Koji Izutsu, Nathan Hale Fowler, Xiaonan Hong, et al.

Efficacy and time to next treatment following lenalidomide/rituximab (R2) or rituximab/placebo in patients with R/R indolent NHL (AUGMENT).

Conclusions: These analyses suggest that R2 (vs R/placebo) prolonged time to subsequent treatment and is associated with longer PFS2, enabling greater response to next therapy. Although patient numbers were modest, it is hypothesized that patients who received R2 were generally more sensitive to subsequent therapy than those treated with R/placebo. Clinical trial information: NCT01938001

Response to next treatment after R2 and R/placebo.
Treatment (R2 n/ R/placebo n) Response after R2
 Response after R/placebo
ORR, % CR, % ORR, % CR, %
Single agent chemo (n = 8/14) 63 38 36 21
Other R-Chemo combo (n = 7/11) 43 29 64 18
Other (n = 9/10) 44 22 40 30
Combo chemo (n = 2/15) 0 0 27 0
Single agent targeted therapy (n = 7/8) 43 14 13 0
R-Benda (n = 5/10) 100 40 40 30
R monotherapy (n = 3/4) 67 67 25 0
O-Chemo (n = 3/3) 100 67 67 33
R-CHOP (n = 3/2) 67 33 0 0
Combo targeted therapies (n = 2/3) 50 0 33 33

 

Jeremy S. Abramson, Maria Lia Palomba, Jon E. Arnason, Matthew Alexander Lunning, et al.

 
Conclusions: In the ongoing TRANSCEND NHL 001 study, liso-cel continues to demonstrate the ability to be safely delivered to pts with R/R B-cell NHL, including those with secondary CNS lymphoma, a population of pts with a highly unmet medical need. No excess NE was noted in this population. This cohort continues to be evaluated. Clinical trial information: NCT02631044