ADVANCES IN CAR T-CELL TREATMENT

L.W. Kwak, Duarte, CA (USA), et al.

NOVEL BAFF-R CAR T-CELL THERAPY FOR CD19 ANTIGEN-LOSS RELAPSED B CELL TUMORS

Authors Conclusion from the abstractTaken together, our data suggest that BAFF‐R is amenable to CAR T‐cell therapy and that targeting it may add to existing alternative strategies to overcome relapse from CD19 antigen loss, such as CD22 CAR T cells. Future strategies combining dual targeting of CD19 and BAFF‐R may also be effective.

 

C.L. Batlevi, New York, NY (USA), et al.

PHASE I CLINICAL TRIAL OF CD19-TARGETED 19-28Z/4- 1BBL “ARMORED” CAR T CELLS IN PATIENTS WITH RELAPSED OR REFRACTORY NHL AND CLL INCLUDING RICHTER TRANSFORMATION

Authors Conclusion from the abstractTreatment with 19‐28z/4‐1BBL armored CAR T cells is safe with no severe CRS. Grade 3 neurotoxicity was noted in 3 pt (11%) with no case of cerebral edema. The overall CR rate is 57% with 8 patients remaining in CR at the time of this report. Future studies are warranted to develop and improve on existing CAR T cell therapies.

 

C.A. Ramos, Houston, TX (USA), et al.

CD30-CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS FOR THERAPY OF HODGKIN LYMPHOMA (HL)

Authors Conclusion from the abstractTwelve patients have been evaluated at 6 weeks after infusion. Seven have had a CR lasting up to >15 months, 1 had a partial response, and 4 had disease progression. In 2 patients who relapsed after CR and were re‐biopsied, immunohistochemistry evidenced persistent tumor expression of CD30. Hence, infusion of CD30.CARTs after cytoreductive chemotherapy is well tolerated at the doses used. Inclusion of cytoreduction pre‐infusion substantially improves CD30.CART expansion and appears associated with superior anti‐tumor activity in relapsed patients.

 

J. Gauthier, Seattle, WA (USA), et al.

DURABLE RESPONSES AFTER CD19-TARGETED CAR-T CELL IMMUNOTHERAPY WITH CONCURRENT IBRUTINIB FOR CLL AFTER PRIOR IBRUTINIB FAILURE

Authors Conclusion from the abstractIn conclusion, CD19 CAR‐T cell therapy with concurrent ibrutinib for R/R CLL was feasible and led to high rates of durable responses, without ≥ grade 3 CRS.

 

A.V. Hirayama, Seattle, WA (USA), et al.

HIGH RATE OF DURABLE COMPLETE REMISSION IN FOLLICULAR LYMPHOMA AFTER CD19 CAR-T CELL IMMUNOTHERAPY

Authors Conclusion from the abstractCD19 CAR‐T cell immunotherapy is highly effective in adults with clinically aggressive R/R FL, with durable CR in a high proportion of FL pts.

 

 

T. Siddiqi, Duarte, CA (USA), et al.

SAFETY OF LISOCABTAGENE MARALEUCEL GIVEN WITH DURVALUMAB IN PATIENTS WITH RELAPSED/ REFRACTORY AGGRESSIVE B-CELL  NON-HODGKIN LYMPHOMA: FIRST RESULTS FROM THE PLATFORM STUDY

Authors Conclusion from the abstractBased on preliminary results, the combination of liso‐cel with durvalumab has an acceptable safety profile. No CRS was observed after initiation of durvalumab. Preliminary data suggest CAR T cells persist and/or increase with combination treatment, warranting further clinical evaluation. Updated data will be presented.