Genitourinary tumours, prostate


Cabozantinib (C) in combination with atezolizumab (A) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): results of expanded cohort 6 of the COSMIC-021 Study

Agarwal, et al.


C + A demonstrated clinically meaningful activity with a manageable safety profile in mCRPC, supporting a phase 3 study of C + A versus second NHT (CONTACT-02; NCT04446117).



PRINCE: Interim Analysis of the Phase Ib Study of 177Lu-PSMA-617 in Combination with Pembrolizumab for Metastatic Castration Resistant Prostate Cancer (mCRPC)

S.K. Sandhu, et al.


The combination of Lu-PSMA-617 and pembrolizumab had promising activity. Toxicities were consistent with those of single agent Lu-PSMA-617 and pembrolizumab.



Final overall survival (OS) analysis from ARCHES: a phase 3, randomized, double-blind, placebo (PBO)-controlled study of enzalutamide (ENZA) + androgen deprivation therapy (ADT) in men with metastatic hormone-sensitive prostate cancer (mHSPC)

A.J. Armstrong, et al.


This final analysis demonstrates that ENZA + ADT significantly prolongs survival in men with mHSPC and, together with the acceptable safety profile, supports the clinical benefit of ENZA + ADT in men with mHSPC.