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Kongressberichte 2021
ESMO Congress 2021
Saturday, September 18
Mini oral sessions
Gastrointestinal tumours, colorectal
Gastrointestinal tumours, colorectal
387MO
Tumour mutation profiles and Circulating tumour cells in Metastatic Colorectal Cancer patients treated with FOLFIRI + cetuximab: A Prospective Ancillary Study of the UNICANCER PRODIGE-28 trial
Blons, et al.
Conclusions
This exploratory analysis suggests that patients with any tumour mutation in MAPK pathway genes are not good candidates for maintenance treatment with cetuximab or treatment interruption after first-line FOLFIRI-cetuximab.
388MO
Tumor budding, a important prognostic factor in stage III colon cancer patients treated with oxaliplatin-based chemotherapy
Basile, et al.
Conclusions
In this large series from a randomized phase III trial, TB is an independent prognostic factor for OS and DFS in stage III CC patients treated with oxaliplatin-based standard adjuvant therapy. TB, adopted in the UICC TNM classification, should now be mandatory in every pathology report concerning patients resected from a stage III CC.
389MO
Risk of bowel obstruction in patients undergoing neoadjuvant chemotherapy for high-risk colon cancer: A nested case-control matched analysis of an international, multi-centre, randomised controlled trial (FOxTROT)
Glasbey, et al.
Conclusions
Safe selection for NAC for colon cancer can be informed by using two features that are available before treatment initiation and identify a small number of patients with high risk of preoperative obstruction.
390MO
Colorectal (CRC) cancer screening and diagnosis during the COVID-19 pandemic in Quebec – Canada
Tehfe, et al.
Conclusions
The COVID-19 affected screening and lead to decreased CRC diagnosis rate. Even with the recovery to pre-pandemic activities, catching up with the delays is a challenge for health authorities. The impact of the offloading of diagnostic and surgical activities on cancer mortality is hard to be estimated but is likely to be significant.
391MO
Impact of diabetes and metformin use on recurrence and outcome in early colon cancer (CC) patients – a pooled analysis of 3 adjuvant trials
E.S. Bergen, et al.
Conclusions
CC patients with diabetes type 2 had a significantly worse survival as well as shorter TTR. Furthermore, our data suggest that metformin may attenuate the detrimental effect of diabetes on CC patient outcomes.