Startseite Kongressberichte & Archiv ASCO20 Virtual Scientific Meeting Oral Sessions Lung Cancer I

Lung Cancer—Non-Small Cell Local-Regional/Small Cell/Other Thoracic Cancers

Oncoletter provides you with quotes from the abstract's conclusions. To see more, go the ASCO Meeting Library while clicking on the link of the study-titles (to see videos and slides needs a payable registration) 

9000 Randomized phase II clinical trial of cisplatin/carboplatin and etoposide (CE) alone or in combination with nivolumab as frontline therapy for extensive-stage small cell lung cancer (ES-SCLC): ECOG-ACRIN EA5161.
 
Ticiana Leal, Yating Wang, Afshin Dowlati, et al.
 
The abstract concludes: 
The addition of nivolumab to CE as 1L treatment for ES-SCLC significantly improved PFS and OS. No new safety signals were observed. Clinical trial information: NCT03382561
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9001 KEYNOTE-604: Pembrolizumab (pembro) or placebo plus etoposide and platinum (EP) as first-line therapy for extensive-stage (ES) small-cell lung cancer (SCLC).
 
Charles M. Rudin, Mark M. Awad, Alejandro Navarro, et al.
 
The abstract concludes: 
Pembro + EP significantly improved PFS and prolonged OS compared with placebo + EP as first-line therapy for pts with ES-SCLC. No unexpected toxicities were seen with pembro + EP. These data support the benefit of pembro-containing regimens for ES-SCLC. Clinical trial information: NCT03066778
 
CCO Independent Conference Coverage of the 2020 ASCO Virtual Scientific Meeting:
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9002 Durvalumab ± tremelimumab + platinum-etoposide in first-line extensive-stage SCLC (ES-SCLC): Updated Results from the phase III CASPIAN study.
 
Luis G. Paz-Ares, Mikhail Dvorkin, Yuanbin Chen, et al.
 
The abstract concludes: 
The addition of durvalumab to EP continued to demonstrate improvement in OS compared with a robust control arm, further supporting this regimen as a new standard of care for 1L ES-SCLC offering the flexibility of platinum choice. No additional benefit was observed when T was combined with D + EP in this pt population. Safety findings in all arms remained consistent with the known safety profiles of all agents. Clinical trial information: NCT03043872
 
CCO Independent Conference Coverage of the 2020 ASCO Virtual Scientific Meeting:
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9003 PrE0505: Phase II multicenter study of anti-PD-L1, durvalumab, in combination with cisplatin and pemetrexed for the first-line treatment of unresectable malignant pleural mesothelioma (MPM)—A PrECOG LLC study.
 
Patrick M. Forde, Zhuoxin Sun, Valsamo Anagnostou, et al.
 
The abstract concludes: 
The combination of chemotherapy with durvalumab delivered a promising median OS for previously untreated pts with unresectable MPM. Full results from the study along with the extensive correlative analyses performed will be reported. The phase 3 PrE0506/DREAM3R trial evaluating CP-durvalumab versus CP alone will commence enrollment in the United States and Australia in 2020. Clinical trial information: NCT02899195
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9004 Randomized phase II study on gemcitabine with or without ramucirumab as second-line treatment for advanced malignant pleural mesothelioma (MPM): Results of Italian Rames Study.
 
Maria Pagano, Giovanni Luca Ceresoli, Paolo Andrea Zucali, et al.
 
The abstract concludes: 
In the RAMES Study the addition of Ramucirumab to Gemcitabine significantly improved OS regardless of age of pts, tumor histotype and TTP at the first-line treatment. Gemcitabine plus Ramucirumab can be considered a manageable regimen in second-line treatment of advanced MPM pts.Clinical trial information: NTC03560973.
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The abstract concludes: 
In the RAMES Study the addition of Ramucirumab to Gemcitabine significantly improved OS regardless of age of pts, tumor histotype and TTP at the first-line treatment. Gemcitabine plus Ramucirumab can be considered a manageable regimen in second-line treatment of advanced MPM pts.Clinical trial information: NTC03560973.
 
Read the comment in the ASCO DAILY NEWS:
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9006 Randomized phase III study of irinotecan/cisplatin (IP) versus etoposide/cisplatin (EP) for completely resected high-grade neuroendocrine carcinoma (HGNEC) of the lung: JCOG1205/1206.
 
Hirotsugu Kenmotsu, Seiji Niho, Masahiro Tsuboi, et al.
 
The abstract concludes: 
This study failed to show the superiority of IP to EP in RFS for pts with completely resected HGNEC. EP is still a standard treatment for this population. Clinical trial information: UMIN000010298.
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9007 Randomized phase II trial comparing the efficacy of standard-dose with high-dose twice-daily thoracic radiotherapy (TRT) in limited disease small-cell lung cancer (LD SCLC).
 
Bjorn Henning Gronberg, Kristin Toftaker Killingberg, Øystein Fløtten, et al.
 
The abstract concludes: 
LD SCLC patients who received BID TRT of 60 Gy had a statistically significant and numerically substantial benefit in terms of 2-year survival (primary endpoint) and median overall survival compared with those who received BID TRT of 45 Gy. The higher TRT dose did not cause more toxicity than the standard dose. Clinical trial information: NCT02041845
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Limited-Stage Small Cell Lung Cancer: Have We Finally Defined Radiation Standards?
 
DISCUSSANT
Percy Lee, MD | University of Texas MD Anderson Cancer Center
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Poster Abstract

9036 Efficacy of DNA versus RNA NGS-based Methods in MET Exon 14 skipping mutation detection.

Magdalena Jurkiewicz, Anjali Saqi, Mahesh M Mansukhani, et al.

The abstract concludes: 
DNA based NGS-panels can potentially miss MET-ex14 skipping events in lung carcinomas, when the primers do not target both 3′ splice site of intron 13, and the 5′ splice site of intron 14. A reflex work flow interrogating RNA fusions can potentially capture such events. The clinical and molecular characterization of the variants detected only by RNA NGS assays warrants further exploration.
 
Simultaneously published on NEJM:

Tepotinib in Non–Small-Cell Lung Cancer with MET Exon 14 Skipping Mutations

P.K. Paik and Others

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9069 RESILIENT part I, an open-label, safety run-in of liposomal irinotecan in adults with small cell lung cancer (SCLC) who have progressed with platinum-based first-line (1L) therapy: Subgroup analyses by platinum sensitivity.

David R. Spigel, Luis G. Paz-Ares, Yuanbin Chen, et al.

The abstract concludes:

ORR and DCR12wks were numerically higher in platinum-sensitive than in platinum-resistant patients with SCLC who had progressed with platinum-based 1L therapy before receiving 2L liposomal irinotecan 70 mg/m2 in this phase 2 study. RESILIENT part 2, an ongoing, phase 3, randomized controlled trial vs topotecan, will provide further data. Clinical trial information: NCT03088813

CCO Independent Conference Coverage of the 2020 ASCO Virtual Scientific Meeting:
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TPS9081 RESILIENT part II: an open-label, randomized, phase III study of liposomal irinotecan injection in patients with small-cell lung cancer who have progressed with platinum-based first-line therapy.

Luis G. Paz-Ares, David R. Spigel, Yuanbin Chen, et al.

  • The primary endpoint is overall survival (OS) and secondary endpoints are progression-free survival (PFS), objective response rate, and proportion of patients reporting symptom improvement.

Clinical trial information: NCT03088813

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MORE ABSTRACTS:
 
Clinical Science Symposium
MET Mutations: The Meat of the Matter
 
Poster Discussion Session
Lung Cancer—Non-Small Cell Local-Regional/Small Cell/Other Thoracic Cancers
 
Poster Session
Lung Cancer—Non-Small Cell Local-Regional/Small Cell/Other Thoracic Cancers
 
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Lung (Abstracts #LBA5, 9000, 9001)
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