623. Mantle Cell and Indolent B-Cell Lymphoma - CAR-T and immunotherapy clinical studies

Caron Jacobson, Julio C. Chavez, Alison R. Sehgal, et al. 

Authors Conclusion from the Abstract: Axi-cel had considerable and durable clinical benefit in patients with iNHL, with high ORR and CR rates. Axi-cel had a manageable safety profile, with lower rates of Grade ≥ 3 NEs observed in patients with FL vs those in patients with MZL and those previously reported in aggressive NHL (Locke, et al. Lancet Oncol. 2019).

Francisco J. Hernandez-Ilizaliturri, Ian W. Flinn, John Kuruvilla, et al.

Authors Conclusion from the Abstract: TRPH-222 monotherapy is well tolerated through dose-escalation to 10 mg/kg, with a low incidence of AEs commonly associated with ADCs such as thrombocytopenia, neutropenia, and peripheral neuropathy. The most common AEs included low grade and manageable ocular findings consistent with known epithelial keratopathy of ADCs bearing microtubule inhibitors. These data, together with 100% CD22 receptor occupancy observed at all dose levels, and CRs/PRs observed at doses levels less than 10 mg/kg, support further assessment of TRPH-222 monotherapy in an expansion cohort currently enrolling R/R FL and DLBCL patients. These results support further clinical studies of TRPH-222, including combinations with other antitumor agents in B-cell lymphoma patients.

Sarit E Assouline, Won Seog Kim, Laurie H. Sehn, et al. 

Authors Conclusion from the Abstract: Fixed-duration mosunetuzumab monotherapy results in high response rates and durable disease control with a tolerable safety profile in heavily pretreated patients with FL, including known high-risk subgroups. Updated pharmacodynamics and biomarker data will be presented at the meeting.

Grzegorz S. Nowakowski, Lori A. Leslie, Anas Younes, et al.

Authors Conclusion from the Abstract: CA-4948 demonstrates good safety profile, desirable pharmacokinetic properties, and preliminary clinical activity. Enrollment is ongoing to support the anticipated RP2D of 300 mg bid. These encouraging results provide clinical validation of IRAK4 as a viable, novel therapeutic target in B-cell malignancies will lead to clinical combinations with synergistic drugs including BTK or BCL2 inhibitors [3] in patients with advanced hematological malignancies. Clinical trial: NCT03328078.

Samuel Yamshon, Peter Martin, Bijal Shah, et al.

Authors Conclusion from the Abstract: Lenalidomide and rituximab as initial treatment for MCL can achieve high rates of complete responses with durable remissions in both elderly and younger patients, with many patients maintain remissions now extending beyond 7 years. Toxicity was not significantly affected by continuous treatment, and close follow up was able to limit toxicity for those who wished to remain on therapy. It is notable that this combination offers a chemotherapy-free initial approach which compares favorably in outcome to conventional outpatient chemotherapy-based regimens such as bendamustine-rituximab, VR-CAP, and R-CHOP with rituximab maintenance. Further evaluation of this active regimen in larger, randomized frontline trials comparing novel agents with chemoimmunotherapy is warranted. (ClinicalTrials.gov - NCT01472562)