624. Hodgkin Lymphomas and T/NK cell Lymphomas: T/NK Cell Lymphoma Relapsed Therapy


Steven M. Horwitz, Anastasia Nikitina, Nikita Kotlov, et al.

DR is highly active at R / R PTCL with an ORR of 58 percent and a CR of 42 percent. In addition, the tolerable DR provided an adequate response to allow frequent bridging to ASCT. In contrast to D alone, DR caused lower rates of transaminitis and had higher rates of CR. TET2 mutations and greater involvement of B cells predicted a response. TP53 mutations were only seen in NR. Biomarker-driven patient selection could further improve the ORR to DR.



Krimo Bouabdallah, Raphaëlle Aubrais, Loïc Chartier, et al.

The results of BBV in the treatment of R / R PTCL show a high response rate, a long DoR in responding patients and a very good outcome. Patients in CR eligible for transplant have the best outcome. Thus, in these high-risk lymphomas with limited treatment options, this combination is a good candidate for salvage therapy prior to transplant consolidation.



Thomas E. Witzig, Lubomir Sokol, Won Seog Kim, et al.

Tipifarnib has shown very encouraging efficacy in patients with CXCL12-expressing subtypes of PTCL (AITL and PTCL-CXCL12 +). The data show a tolerable safety profile.



Steven M. Horwitz, Tatyana A. Feldman, Jing C. Ye, et al.

A complete and sustained response to cerdulatinib has been observed in patients with the AITL / TFH subtype. This also applies to patients with repeated relapses and / or who were refractory to their last treatment. The substance has acceptable tolerability and clinical activity in PTCL. The benefit-risk profile appears to be favorable in this population. Exception: the PTCL-NOS subgroup, in which no response was observed. This subtype-specific activity motivates the identification of biomarkers in order to optimize patient selection.



Bradley M. Haverkos, Onder Alpdogan, Robert Baiocchi, et al.

In patients with R/R-EBV + lymphomas, particularly refractory T/NK-NHL, a heterogeneous group of aggressive lymphomas with a dismal outcome, Nstat plus VGCV showed promising efficacy with several lasting responses. The combination has a manageable toxicity profile and is well tolerated.


624 ASH denotes this abstract as clinically relevant

Henry S. Ngu, Stephen Parkin, David W. Scott, et al.

According to the authors, the results in the ITT R / R PTCLs are suboptimal: only about 1/3 of the patients have long-term survival. But if they receive an SCT, then more than half are still alive after 5 years. A third line of therapy can be a successful bridge to SCT. Then new active ingredients should be considered. Despite more refractory patients, the results with allo-SCT are encouraging.