642. CLL: Therapy, excluding Transplantation: Combination and Novel Treatment

Conclusion cited from the abstract: 

Four-year data from MURANO demonstrate sustained PFS and OS benefits with VenR versus BR. 24-month post-treatment cessation PFS was 68.0% in pts completing 2 years of Ven, and pts who attained PB uMRD showed particularly durable responses. These follow-up data provide further support for the application of time-limited VenR in R/R CLL.

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356

Conclusion cited from the abstract: 

We identified genomic alterations having impact on MRD response at EOCT and EOT (i.e. BIRC3, BRAF, NOTCH1, TP53): mutations mostly were associated with increased MRD and del17p tended to lead to increase in high and low clones of MRD+. Low/high GC negatively impacted long-term PFS with VenR and may represent high-risk pt subgroups. High BCL-2 may associate with MRD+ at EOCT but not at EOT. Given the small size of the genomic alteration cohort, further validation of these findings are needed. Studying the large CLL clinicogenomic data in MURANO helped determine whether VenR combinations overcome challenges posed by CLL/SLL with unfavorable clinical characteristics, and further identify biomarkers that may predict clinical benefits in these pts.

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357

Conclusion cited from the abstract: The iFCG regimen with only 3 cycles of chemotherapy is an effective time-limited regimen for young pts with M-IGHV and without del(17p)/ mutated TP53.

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358

Conclusion cited from the abstract: 

Ven added to ibr in pts with high-risk CLL as consolidation is well tolerated and associated with a high likelihood of achieving U-MRD in BM and CR within 12 months of combination therapy, suggesting that time-limited therapy may be feasible in high-risk CLL. Further follow-up will determine the likelihood of achieving U-MRD at later time points and durability of responses.

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359

Conclusion cited from the abstract: Combined VEN and IBR is an effective well-tolerated chemotherapy-free oral regimen for pts with R/R CLL.

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360

Conclusion cited from the abstract: 

We established the phase 2 dose of Umbra + Ubli + Ven and demonstrated good tolerability in pts with relapsed or refractory CLL. Preliminary results suggest that this chemotherapy-free regimen can provide undetectable MRD after only 12 cycles, representing an effective treatment plan for this population. Ongoing enrollment is focused on pts who have relapsed after BTK inhibitors and a multi-center trial is planned to further develop the triplet regimen.

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